The Johnson Space Center (JSC) in Houston, Texas, is NASA’s premier hub for human space exploration and a cornerstone of American technological innovation. Established on November 1, 1961, as the Manned Spacecraft Center, JSC was rechristened in 1973 to honor President Lyndon B. Johnson, a key advocate for the U.S. space program. Located in the Clear Lake area, JSC was strategically chosen for its proximity to water transport, a major airport, robust telecommunications, and a vibrant academic and industrial ecosystem. JSC is best known as the home of Mission Control, the operational nerve center for every American human spaceflight, from the Gemini and Apollo missions to the Space Shuttle and the International Space Station (ISS). It played a pivotal role in achieving President Kennedy’s goal of landing humans on the Moon, with the iconic words “Houston, the Eagle has landed” echoing from the lunar surface in 1969. The center also led the design, development, and operation of spacecraft, astronaut training, and scientific research, including the quarantine and study of lunar samples after Apollo missions. Today, JSC remains at the forefront of space exploration, directing ISS operations, supporting commercial spaceflight partnerships, and advancing research for future missions to the Moon and Mars. With over 12,000 employees, JSC fosters collaboration with industry, academia, and global partners, driving technological breakthroughs and economic growth. Its legacy is celebrated at Space Center Houston, the official visitor center, which showcases historic spacecraft and offers immersive experiences. JSC’s enduring impact on science, technology, and business continues to inspire innovation and shape the future of space exploration.